What is the best way to get from Miami to Key West?
It is a long, scenic run down the Overseas Highway, best with a driver, often a half-day each way; times vary a lot with traffic. That is the honest version — the number a map gives you is the version with no traffic, no rain and nobody else going the same way, and this route rarely offers all three.
Depending on the route, the options are a train where one runs (Brightline links Miami, Aventura, Fort Lauderdale, Boca Raton, West Palm Beach and Orlando), driving yourself, an app, or a car booked ahead (Brightline, n.d.). A train still leaves you at a station with your luggage; a car booked ahead goes door to door. Driving yourself means parking at the other end and staying dry, sober and unbothered for the whole run. An app means standing at the kerb hoping someone accepts a long fare, and the fare can change with demand. The longer the trip, the worse that trade gets.
Flying in, the choice is MIA or EYW. The nearer airport is not always the faster door-to-door once the drive is counted, and the concierge will say plainly which one works better for your timing.
Booked ahead, the car is yours for the whole run: one driver, one fare agreed before it starts, luggage handled at both ends, and a car that waits if you are late rather than leaving. If you are going Key West and back the same day, the same car and the same driver hold the return, which is usually the half people forget to plan.
Duval and the waterfront hold the tables; in Old Town you'll often walk. The car matters for the marina dinners and the trip in. Most of these trips end up somewhere around Old Town, Duval Street, the waterfront.